Department of Integrative Biology


 Head:

Rafał Ciosk,PhD,

Associate Prof. ICHB PAS




 

Staff:

Takashi Miki, PhD;

Edyta Kościańska, PhD;

Jarosław Lewandowski, PhD;

Agnieszka Chabowska-Kita, PhD;

Daria Sobańska, PhD;

Weronika Wendlandt-Stanek, PhD

 

PhD Students:

Aneta Bilnicka, MSc;

Alicja Komur, MSc Eng.;

Bogna Juskowiak, MSc




 

 

 

 

 

 

 

 

 

 

 

Laboratory affiliated to the Department:

Laboratory of Subcellular Structures Analyses

Laboratory of Animal Model Organisms

 

Keywords:

Gene regulation, RNA biology, development, pluripotency, metabolism, fat regulation

 

Research area:

- Posttranscriptional gene regulation

- Cytoplasmic roadblocks to cellular reprograming

- Regulation of fat metabolism


Ongoing research projects:

1. Cytoplasmic roadblocks in cell fate reprogramming: from players to molecular mechanisms.
NCN – OPUS 10

2. Regulation of body fat: from novel mechanisms to therapeutic targets.
FNP – TEAM

3. Cell fate plasticity in animal development and tissue homeostasis.
EMBO – INSTALLATION GRANT

 

Selected publications from the last three years:

1. Fassnacht C, Tocchini C, Kumari P, Gaidatzis D, Stadler MB, and Ciosk R
The CSR-1 endogenous RNAi pathway ensures accurate transcriptional reprogramming during the oocyte-to-embryo transition in Caenorhabditis elegans.
PLOS Genetics 14(3): e1007252 (2018)

2.Kumari P, Aeschimann F, Gaidatzis D, Keusch JJ, Ghosh P, Neagu A, Pachulska-Wieczorek K, Bujnicki JM, Gut H, Großhans H, and Ciosk R
Evolutionary plasticity of the NHL domain underlies distinct solutions to RNA recognition.
Nature Communications 9, 1549 (2018)

3. Aeschimann F, Kumari P, Bartake H, Gaidatzis D, Ciosk R, and Großhans H.
LIN41 post-transcriptionally silences mRNAs by two distinct and position-dependent mechanisms.
Mol Cell 65; 476-89 (2017)

4. Habacher C, Guo Y, Venz R, Kumari P, Neagu A, Gaidatzis D, Harvald E, Færgeman N, Gut H, and Ciosk R
Ribonuclease-mediated control of body fat.
Dev Cell 39,359-369 (2016)

5. Fassnacht C and Ciosk R
Cell fate maintenance and reprogramming during the oocyte-to-embryo transition.
In the Springer series Results and Problems in Cell Differentiation 59, 269-86 (2017)

6. Habacher C and Ciosk R
ZC3H12A/MCPIP1/Regnase-1-related endonucleases: An evolutionary perspective on molecular mechanisms and biological functions.
BioEssays 39 (2017)

7. Seelk S, Kalchhauser I, Hargitai B, Hajduskova M, Gutnik S, Tursun B, and Ciosk R
Increasing Notch signaling antagonizes PRC2-mediated silencing to promote reprogramming of germ cells into neurons.
eLife 5:e15477 (2016).

8. Tocchini C and Ciosk R
TRIM-NHL proteins in development and disease.
Seminars Cell and Dev Biol 47-8, 52-9 (2015)