Department of Molecular Genetics


Members:

Head of Department:

Piotr Kozłowski, Prof. 

 

 


Staff:

Marzena Wojciechowska, Prof.

Anna Jasińska, Prof., currently at Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, USA

Paulina Gałka-Marciniak, PhD

Martyna Urbanek- Trzeciak, PhD

Malwina Suszyńska, PhD

Katarzyna Chojnacka, MSc


 

PhD Students:

Paulina Nawrocka, MSc

 


 
 

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Keywords:
cancer genetics, copy number variation polymorphism (CNV), multiplex ligation-dependent probe amplification (MLPA), miRNA, ncRNA, circRNA, ddPCR

Research area:

  • cancer genetics
  • development of technologies for CNV polymorphism genotyping,
  • genetic polymorphism and somatic variation of microRNA genes,
  • computational analysis of copy number variation polymorphism in the human genome and other eukaryotic genomes
  • circRNA expression level analysis in myotonic dystrophy (DM1)

Ongoing research projects:
1. Analysis of somatic mutations in miRNA and miRNA-biogenesis genes to identify new
therapeutic targets and biomarkers of cancer.
NSC – MAESTRO 8- 2016/22/A/NZ2/00184, PI: P. Kozłowski, Prof.

2. Analysis of the role of BARD1 gene in genetic predisposition to breast cancer - utilization of unique strategy of association analysis of founder mutations.
NSC – OPUS 9- 2015/17/B/NZ2/01182, PI: P. Kozłowski, Prof.

Selected publications
Suszynska M, Klonowska K, Jasinska AJ, Kozlowski P. Large-scale meta-analysis of mutations identified in panels of breast/ovarian cancer-related genes - Providing evidence of cancer predisposition genes. Gynecol Oncol. 2019 May;153(2):452-462. doi: 10.3390/cancers11060740.

Czubak K, Taylor K, Piasecka A, Sobczak K, Kozlowska K, Philips A, Sedehizadeh S, Brook JD, Wojciechowska M, Kozlowski P. Global increase in circRNA levels in myotonic dystrophy. Front Genet 2019 Jul 18;10:649. doi: 10.3389/fgene.2019.00649.

Galka-Marciniak M, Urbanek-Trzeciak MO, Nawrocka PM, Dutkiewicz A, Giefing M, Lewandowska MA, Kozlowski P. Somatic mutations in miRNA genes in lung cancer – potential functional consequences of non-coding sequence variants. Cancers(Basel) 2019 Jun 8;11(6). doi: 10.3390/cancers11060793

Suszynska M, Kluzniak W, Wokolorczyk D, Jakubowska A, Huzarski T, Gronwald J, Debniak T, Szwiec M, Ratajska M, Klonowska K, Narod S, Bogdanova N, Dörk T, Lubinski J, Cybulski C, Kozlowski P. BARD1 is A Low/Moderate Breast Cancer Risk Gene: Evidence Based on An Association Study of the Central European p.Q564X Recurrent Mutation. Cancers (Basel). 2019 May 28;11(6). doi: 10.1016/j.ygyno.2019.01.027.

Czubak K, Sedehizadeh S, Kozlowski P, Wojciechowska M. An Overview of Circular RNAs and Their Implications in Myotonic Dystrophy. Int J Mol Sci. 2019 Sep 6;20(18). doi: 10.3390/ijms20184385.

Stolarek I, Handschuh L, Juras A, Nowaczewska W, Kóčka-Krenz H, Michalowski A, Piontek J, Kozlowski P, Figlerowicz M. Goth migration induced changes in the matrilineal genetic structure of the central-east European population. Sci Rep. 2019 May 1;9(1):6737. doi: 10.1038/s41598-019-43183-w.

Dabrowska M, Czubak K, Juzwa W, Krzyzosiak WJ, Olejniczak M, Kozlowski P. qEva-CRISPR: a method for quantitative evaluation of CRISPR/Cas-mediated genome editing in target and off-target sites. Nucleic Acids Res. 2018 28;46(17):e101, DOI: 10.1093/nar/gky505.

Klonowska K, Kluzniak W, Rusak B, Jakubowska A, Ratajska M, Krawczynska N, Vasilevska D, Czubak K, Wojciechowska M, Cybulski C, Lubinski J, Kozlowski P. The 30 kb deletion in the APOBEC3 cluster decreases APOBEC3A and APOBEC3B expression and creates a transcriptionally active hybrid gene but does not associate with breast cancer in the European population. Oncotarget. 2017 Jul 19;8(44):76357-76374.

Philips A, Stolarek I, Kuczkowska B, Juras A, Handschuh L, Piontek J, Kozlowski P, Figlerowicz M. Comprehensive analysis of microorganisms accompanying human archaeological remains. Gigascience. 2017 Jul 1;6(7):1-13.

Klonowska K, Czubak K, Wojciechowska M, Handschuh L, Zmienko A, Figlerowicz M, Dams-Kozlowska H, Kozlowski P. Oncogenomic portals for the visualization and analysis of genome-wide cancer data. Oncotarget. 2016 Jan 5;7(1):176-92.