Department of Developmental Biology

Members

Head of Department:

Takashi Miki, Ph.D.
Prof. ICHB PAN

Takashi Miki

PhD students:

İlkin Aygün, MSc


Research activities


Figure 1
Characterizing RNA degradation pathways essential for animal development, by combining C. elegans genetics and quantitative transcriptomics.
Figure 1
Characterizing RNA degradation pathways essential for animal development, by combining C. elegans genetics and quantitative transcriptomics.

Figure 2
Elucidating developmental roles of XRN2 using tissue-specific conditional mutants of XRN2.
Figure2
Elucidating developmental roles of XRN2 using tissue-specific conditional mutants of XRN2.

Figure 3 Elucidating mechanisms of XRN2-dependent and –independent transcription termination
Figure 3
Elucidating mechanisms of XRN2-dependent and –independent transcription termination

Research area

We aim to understand how RNA regulation supports animal development, using C. elegans as a model system. Our current focus includes:
• Developmental roles of the exoribonuclease XRN2
• Mechanisms of transcription termination

Key topics

• RNA regulation
• Ribonucleases
• RNA-binding proteins
• Transcription termination
• Animal development

Research projects

Ongoing research projects

Mechanisms and developmental roles of transcription termination
NCN OPUS 16

Scientific publications

Selected scientific publications

Miki TS, Carl SH, Großhans H
Two distinct transcription termination modes dictated by promoters.
Genes Dev 31: 1870-1879 (2017). doi: 10.1101/gad.301093.117.

Miki TS, Carl SH, Stadler MB, Großhans H
XRN2 autoregulation and control of polycistronic gene expression in Caenorhabditis elegans.
PLoS Genet 12: e1006313 (2016). doi: 10.1371/journal.pgen.1006313.

Rüegger S, Miki TS, Hess D, Großhans H
The ribonucleotidyl transferase USIP-1 acts with SART3 to promote U6 snRNA recycling.
Nucleic Acids Res 43: 3344-3357 (2015). doi: 10.1093/nar/gkv196.

Miki TS, Richter H, Rüegger S, Großhans H
PAXT-1 promotes XRN2 activity by stabilizing it through a conserved domain.
Mol Cell 53: 351-360 (2014). doi: 10.1016/j.molcel.2014.01.001.

Miki TS, Rüegger S, Gaidatzis D, Stadler MB, Großhans H
Engineering of a conditional allele reveals multiple roles of XRN2 in Caenorhabditis elegans development and substrate specificity in microRNA turnover.
Nucleic Acids Res 42: 4056-4067 (2014). doi: 10.1093/nar/gkt1418.