Katarzyna J. PURZYCKA, Ph. D.
RNA Structure and Function Laboratory,
Institute of Bioorganic Chemistry, Polish Academy of Sciences,
61-704 Poznan, Noskowskiego 12/14, Poland.

phone:

(+48-61) 8528503

fax:

(+48-61) 8520532


e-mail: purzycka@ibch.poznan.pl




EDUCATION & POSITIONS:

2004

- M.Sc. in Chemistry at the Faculty of Chemistry, Adam Mickiewicz Uniwersity in Poznań, with the "Maxima Cum Laude" award

2009

- Ph.D. in chemistry, specialization biochemistry, Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznań; thesis "Structural polymorphism of the leader RNA region in a view of the dimerization of the HIV-2 genome and its accessibility for the RNA- targeted therapy" (under supervision of Prof. R. W. Adamiak); with award

2009-2012

- Assistant IBCh PAS, Laboratory of Structural Chemistry of Nucleic Acids

2009-2012

- NIH Visiting fellow in the RT Biochemistry Section, HIV Drug Resistance Program, National Cancer Institute – Frederick

Since 2012

- Assistant Professor IBCh PAS, RNA Structure and Function Laboratory



FELLOWSHIPS:

2004

- Leonardo da Vinci program, Training course in Rhodia Recherches, Lyon, France

2008

- Visiting Scientist, Department of Chemistry, University Science Laboratories, Durham, United Kingdom

2009-1012

- NIH Visiting fellow in the RT Biochemistry Section, HIV Drug Resistance Program, National Cancer Institute - Frederick



COLLABORATIONS:

David J. Garfinkel, Ph. D
Professor of Biochemistry and Molecular Biology
Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602 USA

Stuart F. J. Le Grice, Ph. D
Chief of RT Biochemistry Section, HIV Drug Resistance Program
Head of Center of Excellence in HIV/AIDS and CancerVirology
Frederick National Laboratory for Cancer Research, National Institutes of Health, Frederick, MD 21702, USA

Jef D. Boeke, Ph.D., D.Sc.
Professor of Molecular Biology and Genetics
Professor of Oncology
Department of Molecular Biology and Genetics, The High Throughput Biology Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205,USA



PUBLICATIONS (2004-):

K. J. Purzycka, M. Legiewicz., E. Matsuda, L. D. Eizentstat, S. Lusvarghi, A. Saha, S. F. J. Le Grice, D. J. Garfinkel, Exploring Ty1 retrotransposon RNA structure within virus-like particles. Nucleic Acids Res, 41, 436-473, (2013)

Purzycka KJ, Garfinkel DJ, Boeke JD, Le Grice SF. Influence of RNA structural elements on Ty1 retrotransposition. Mob Genet Elements. (2013);3(2):e25060

M. Chamanian, K. J. Purzycka, J. S. Ha, D. McDonald, Y. Gao, S. F.J. Le Grice, E. J. Arts, Interplay between retroviral genomic RNA packaging and mRNA translation. Cell Host and Microbe, (2013);13(2):181-92. doi: 10.1016/j.chom.2013.01.007

Q. Huang, K.J. Purzycka*, S. Lusvarghi, S.F.J. Le Grice and J.D. Boeke, Retrotransposon Ty1 RNA contains a 5’ terminal long-range pseudoknot required for efficient reverse transcription. RNA, (2013) ,19(3):320-32. doi: 10.1261/rna.035535.112.

S. Lusvarghi, J. Sztuba-Solinska, K.J. Purzycka, J. Rausch, S. F. J. Le Grice, RNA secondary structure prediction using high-throughput SHAPE. Journal of Video Education, 75:e50243. (2013) doi: 10.3791/50243.

M. Popenda, M. Szachniuk, M. Antczak, K.J. Purzycka, P. Lukasiak, N. Bartol, J. Blazewicz and R.W. Adamiak, Automated 3D structure composition for large RNAs. Nucleic Acids Res, 40, e112, (2012).

K. J. Purzycka, K. Pachulska-Wieczorek and R. W. Adamiak, The in vitro loose dimer structure and rearrangements of the HIV-2 leader RNA, Nucleic Acids Res. 39, 7234-7248 (2011), doi:10.1093/nar/gkr385)

M. Legiewicz, A. S. Zolotukhin, G. R. Pilkington, K. J. Purzycka, M. Mitchell, H. Uranishi, J. Bear, G. N. Pavlakis, S. F.J. Le Grice and B. K. Felber, The RNA transport element of the murine MusD retrotransposon requires long-range intramolecular interactions for function, J. Biol. Chem., (2010). (published online on October 26, 2010, doi:10.1074/jbc.M110.182840 )[pdf]

K. J. Purzycka and R. W. Adamiak, The HIV-2 TAR RNA domain as a potential source of viral-encoded miRNA. A reconnaissance study, Nucleic Acids Symposium Series, 52, 511-512 (2008). [pdf]

K. Pachulska-Wieczorek, K. J. Purzycka and R. W. Adamiak, New, extended hairpin form of the TAR-2 RNA domains points to the structural polymorphism at the 5' end of the HIV-2 leader RNA, Nucleic Acids Res., 34, 2984-2997 (2006). [pdf] [pdf]




Back to the Adamiak Lab