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  • Design and application of regioselectively modified oligoribonucleotides for 1H, 13C, 15N and 19F NMR studies of RNA motifs. Chemistry of nucleoside fluorophores and their introduction into oligonucleotides. Introduction of new photochemical probes to RNA.

  • Secondary and 3D structure of the HIV-2 leader RNA. HIV-2 leader RNA dimerisation and interactions of with metal cations, and recombinant proteins: viral Tat-2 and human cyclin T1, nucleocapsid protein NCp8. Structural accessibility of HIV-2 RNA to RNAi machinery.

  • Studies on the RNA NMR structures: RNA triplet repeats, RNA bulge duplexes and 2'-O-MeRNA / LNA chimera duplexes, RNA quadruplexes.

  • RNA database (RNA FRABASE) and 3D RNA structure prediction (RNAComposer).

  • Automation of the RNA NMR spectra analysis.

  • Virtual NMR laboratory.

& Grants

  • 2 P04A 061 26 "TAR region of the HIV-2 leader RNA and its interactions with the Tat-2 and cyclin T1 proteins.", (R.W. Adamiak, K. Pachulska-Wieczorek), 2004-2006

  • Professorial Grant of the Foundation for Polish Science in natural sciences and medicine "The structure of the HIV-2 leader RNA and its availability for the specific degradation according to the RNAi mechanism in a view of AIDS therapy.", (R.W. Adamiak), 2004-2007

  • MNiI: 3 T09A 014 29 "Conformational equilibria and low-resolution 3D structures of the TAR-2 (nt+1-124) and TAR-2+polyA (nt+1-184) domains of the HIV-2 leader RNA in a view of accessibility for the specific degradation according to the siRNA mechanism" (R.W. Adamiak), 2005-2008

  • N301 014 32/0925 "Structural polymorphism of the leader RNA region in a view of the dimerization of the HIV-2 genome and its availability for the RNA-targeted therapy" , (R.W. Adamiak, K.J. Purzycka), 2007-2009

  • MNiI 3 T09A 071 29 "Structure, conformational equilibria and interactions with metal ions of RNA molecules composed of the CXG trinucleotide repeats" (Z. Gdaniec), 2005-2008

  • MNiSZW 2 P04A 033 30 "Structural analysis of the bulged RNA duplexes using biomolecular NMR spectroscopy" (Z. Gdaniec, . Popenda), 2006 - 2008

  • MNiSZW N301 12731/386 "Structural aspects of the thermodynamic stability of 2'-O-MeRNA-LNA/RNA duplexes" (Z. Gdaniec, K. Pasternak), 2006 -2008

  • "Homing" grant of the Foundation for Polish Science, "Small non-coding RNAs as potential targets of new anti-bacterial therapies", (M. Olejniczak), 2006-2008

  • N301 110 32/3871 "The mechanism of the translation regulation by non-coding RNAs as a potential target of new anti-bacterial therapies", (M. Olejniczak), 2007-2009