Ryszard W. ADAMIAK, Ph.D., D.Sc.,
                                       Professor of Chemistry



phone:

(+48-61) 8528503

fax:

(+48-61) 8520532


e-mail: adamiakr@ibch.poznan.pl




EDUCATION & POSITIONS:

1970

- M.Sc. in chemistry, Adam Mickiewicz University, Poznań with award

1974

- Ph.D., organic chemistry, Adam Mickiewicz University, Poznań (under supervision of Prof. M. Wiewiórowski); with award

1982

- habilitation, bio-organic chemistry, Institute of Organic Chemistry, Polish Academy of Sciences, Warsaw

1991

- professor in chemistry, entitled by the President Lech Wałęsa

since 1985

- head of the Laboratory of Structural Chemistry of Nucleic Acids, IBCh PAS



FELLOWSHIPS:

1974 - 1975

- postdoctoral assistantship, King's College University of London, Department of Chemistry (Prof. C.B. Reese), United Kingdom

1981

- 3 months, visiting scientist, University of Illinois at Urbana-Champaign, Department of Biochemistry (Prof. R. Gumport / O.C. Uhlenbeck), USA

1986

- 3 months, visiting professor, Max Planck Institute of Experimental Medicine, Göttingen (Prof. F. Cramer), Germany

1989

- 3 months, visiting professor, Institut für Kristallographie, Freie Universität, Berlin (Prof. W. Saenger), Germany

1991

- 1 month, visiting professor, Tokyo Institute of Technology, Tokyo (Prof. T. Hata), Japan

1999

- 1 month, visiting professor, Tokyo Institute of Technology, Tokyo (Prof. M. Sekine) Japan

2001

- 3 month, visiting professor, Institute of Advanced Energy, Kyoto University (Prof. K. Makino), Japan



MAJOR PUBLICATIONS (1997-):

M. Popenda, E. Biała, J. Milecki and R. W. Adamiak, Solution structure of RNA duplexes containing alternating CG base pairs: NMR study of r(CGCGCG)2 and 2'-O-Me(CGCGCG)2 under low salt conditions, Nucleic Acids Res., 25 (22), 4589-4598 (1997). [pdf]

D. A. Adamiak, J. Milecki, M. Popenda, R. W. Adamiak, Z. Dauter and W. R. Rypniewski, Crystal structure of 2'-O-Me(CGCGCG)2, an RNA duplex at 1.30 Å resolution. Hydration pattern of the 2'-O-methylated RNA, Nucleic Acids Res., 25 (22), 4599-4607 (1997). [pdf]

A. Burdzy, B. Skalski, S. Paszyc, Z. Gdaniec and R. W. Adamiak, Photosensitized Preparation of Fluorescent Luminarosine and Analogues, Nucleosides and Nucleotides, 17, 143-151 (1998).

Ł. Bielecki, T. Kuliński and R. W. Adamiak, Structure and dynamics of adenosine loops in RNA bulge duplexes. RNA hydration at the bulge site, NATO series, RNA Biochemistry and Biotechnology (Eds. J. Barciszewski, B.F.C. Clark).pp 73-87 (1998).

J. Milecki, E. Zamaratski, T. V. Maltseva, A. Földesi, R. W. Adamiak and J. Chattopadhyaya, The First Example of Sequence-specific Non-uniformly 13C5 labelled RNA: Synthesis of the 29mer HIV-1 TAR RNA with 13C Relaxation Window, Tetrahedron, 55, 6603-6622 (1999).

E. Wyszko, J.-P. Fuerste, M. Barciszewska, M. Szymański, R. W. Adamiak, V.A. Erdmann and J. Barciszewski, Preparation of HIV TAR RNA with RNA scissors, J. Biochem., 126, 326-332 (1999).

K. Kulińska, T. Kuliński, A. Lyubartsev, A. Laaksonen and R. W. Adamiak, Spatial distribution functions as a tool in the analysis of ribonucleic acids hydration - Molecular Dynamics studies, Computers and Chemistry, 24, 451-457 (2000).

U. Kaukinen, Ł. Bielecki, S. Mikkola, R. W. Adamiak and H. Lonnberg, The cleavage of phosphodiester bonds within small RNA bulges in the presence and absence of metal ion catalysts, J.Chem.Soc. Perkin Trans. 2, 1024-1031 (2001).

D. A. Adamiak, W.R. Rypniewski, J. Milecki and R. W. Adamiak, The 1.19 Å X-ray structure of 2'-O-Me(CGCGCG)2 duplex shows dehydrated RNA with 2-methyl-2,4-pentanediol in the minor groove, Nucleic Acids Res., 29(20), 4144-4153 (2001). [pdf]

M. Olejniczak, Z. Gdaniec, A. Fischer, T. Grabarkiewicz, Ł. Bielecki and R. W. Adamiak, The bulge region of HIV-1 TAR RNA binds metal ions in solution, Nucleic Acids Res., 30, 4241-4249 (2002). [pdf]

Ł. Bielecki, M. Popenda and R. W. Adamiak, The molecular dynamics thermocycler. A new approach to sample conformational space, as exemplified by the RNA hairpin, Nucleic Acids Research Supplement No. 2, 57-58 (2002).

T. Kuliński, M. Olejniczak, H. Huthoff, Ł. Bielecki, K. Pachulska-Wieczorek, A. T. Das, B. Berkhout and R. W. Adamiak, The Apical Loop of the HIV-1 TAR RNA Hairpin Is Stabilized by a Cross-loop Base Pair, J. Biol. Chem., 278 (40), 38892-38901 (2003). [pdf]

M. Cieslak, J. Szymanski, R. W. Adamiak and C. S. Cierniewski, Structural Rearrangements of the 10-23 DNAzyme to b3 Integrin Subunit mRNA Induced by Cations and Their Relations to the Catalytic Activity, J. Biol. Chem., 278 (48), 47987-47996 (2003). [pdf]

R. W. Adamiak, J. Błażewicz, P. Formanowicz, Z. Gdaniec, M. Kasprzak, M. Popenda and M. Szachniuk, An algorithm for an automatic NOE pathways analysis of 2D NMR spectra of RNA duplexes, J. Comput. Biol., 11 (1), 167-183 (2004).

M. Popenda, J. Milecki and R. W. Adamiak, High salt solution structure of a left-handed RNA double helix, Nucleic Acids Res., 32 (13), 4044-4054 (2004). [pdf]

K. Pachulska-Wieczorek, K. J. Purzycka and R. W. Adamiak, New, extended hairpin form of the TAR-2 RNA domains points to the structural polymorphism at the 5' end of the HIV-2 leader RNA, Nucleic Acids Res., 34, 2984-2997 (2006). [pdf] [pdf]

M. Popenda, Ł. Bielecki and R. W. Adamiak, High-throughput method for the prediction of low-resolution, three-dimensional RNA structures, Nucleic Acids Symposium Series, 50, 67-68 (2006). [Medline]

M. Popenda, M. Błażewicz, M. Szachniuk and R. W. Adamiak, RNA FRABASE version 1.0: an engine with a database to search for the three-dimensional fragments within RNA structures, Nucleic Acids Res., doi: 10.1093/nar/gkm786 (2007); 36 (Database issue) D 386-391 (2008). [pdf]

Ł. Popenda, R.W. Adamiak, Z. Gdaniec, Bulged Adenosine Influence on the RNA Duplex Conformation in Solution, Biochemistry, 47(18), 5059-5067 (2008). [Medline]

K. J. Purzycka and R. W. Adamiak, The HIV-2 TAR RNA domain as a potential source of viral-encoded miRNA. A reconnaissance study, Nucleic Acids Symposium Series, 52, 511-512 (2008). [pdf]

W. Rypniewski, D.A. Adamiak, J. Milecki and R.W. Adamiak, Noncanonical G(syn)-G(anti) base pairs stabilized by sulphate anions in two X-ray structures of the (GUGGUCUGAUGAGGCC) RNA duplex, RNA, 14(9), 1845-1851 (2008). [Pdf]

Ł. Popenda, Ł. Bielecki, Z. Gdaniec, R.W. Adamiak, Structure and dynamics of adenosine bulged RNA duplex reveals formation of the dinucleotide platform in the C:G-A triple, Arkivoc, 3, 130-144 (2009). [pdf]

D. A. Adamiak, J. Milecki, R. W. Adamiak and W. Rypniewski The hydration and unusual hydrogen bonding in the crystal structure of an RNA duplex containing alternating CG base pairs, New J. Chem., 2010, DOI: 10.1039/B9NJ00601J [link]

M. Popenda, M. Szachniuk, M. Blazewicz, S. Wasik, E.K. Burke, J. Blazewicz, R.W. Adamiak, RNA FRABASE 2.0: an advanced web-accessible database with the capacity to search the three-dimensional fragments within RNA structures., BMC Bioinformatics, 2010, 11:231 (published online on May 6, 2010, doi:10.1186/1471-2105-11-231)

Katarzyna J. Purzycka, Katarzyna Pachulska-Wieczorek and Ryszard W. Adamiak, The in vitro loose dimer structure and rearrangements of the HIV-2 leader RNA, Nucleic Acids Res. 39, 7234-7248 (2011), doi:10.1093/nar/gkr385)




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