The Laboratory's current aim is to understand the structure, function and interactions of the functionally important domains of RNA on atomic and molecular level.
The idea is to combine, within the Laboratory, chemistry, molecular biology, structural and calculation lines of research in the RNA field.
The Laboratory encompasses Biomolecular NMR Group (Zofia Gdaniec). Our particular areas of interest include: (i) structure of retroviral RNAs (HIV-1, HIV-2) and retroelements, their interactions with metal ions and proteins (Tat-2, cyclin T1, NCp8) and the accessibility in view of RNAi applications, (ii) NMR structure of non-helical RNA regions, 2'-O-MeRNA / LNA chimera duplexes, RNA triplet repeats, RNA quadruplexes, Z-RNA, (iii) RNA structural databases (FRABASE), methods directed toward 3D RNA structure prediction (RNAComposer).
M. Popenda, M. Blazewicz, M. Szachniuk and R.W. Adamiak, RNA FRABASE version 1.0: an engine with a database to search for the three-dimensional fragments within RNA structures.
Nucleic Acids Research, 36, D386-D391 (2008). (published online on October 5, 2007) [pdf] [pdf]
M. Popenda, M. Szachniuk, M. Blazewicz, S. Wasik, E.K. Burke, J. Blazewicz, R.W. Adamiak. RNA FRABASE 2.0: an advanced web-accessible database with the capacity to search the three-dimensional fragments within RNA structures.
BMC Bioinformatics, 2010, 11:231 (published online on May 6, 2010, doi:10.1186/1471-2105-11-231)